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KMID : 0605620110180010025
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Journal of Korean Society of Biological Psychiatry
2011 Volume.18 No. 1 p.25 ~ p.35
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A Study of the Relationships between the Ratio of 2nd to 4th Digit Length and Cerebral Laterality
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Kim Ah-Young
Kim Seong-Kyun
Youn Jin-Young
Jeong Jae-Seung
Lee Joo-Ho
Chae Jeong-Ho
Lee Yu-Sang
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Abstract
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Objectives: Cerebral laterality is thought to be an important marker for neurodevelopment. Prenatal testosterone could influence both cerebral laterality and 2nd to 4th finger length ratio(2D:4D). EEG coherence and 2D:4D were examined to investigate the relationship between prenatal testosterone level and cerebral laterality.
Methods: EEG was recorded in 24 healthy subjects in the eyes closed resting state. Differences in 2D:4D finger ratio were used to discriminate "masculine finger type" and "feminine finger type" groups. The 2D:4D ratio was lower and greater than one for the "masculine finger type" group and "feminine finger type" group, respectively. We used coherence analysis to estimate the cortical functional connectivity.
Results: There were statistically meaningful relationships among cerebral functional connectivity, sex and finger ratio. Man and masculine finger type group showed higher intra-hemispheric coherence than those of woman and feminine finger type group. Woman and feminine finger type group showed higher inter-hemispheric coherence than those of man and masculine finger type group.
Conclusions: These results imply that prenatal testosterone might act as important determinants of cerebral laterality. Further examination of the relationship between 2D:4D and EEG coherence in schizophrenia could give some clues for the neurodevelopmental hypothesis of schizophrenia genesis.
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KEYWORD
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2nd to 4th digit ratio(2D：4D), EEG coherences, Cerebral laterality
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